1. Synthetic Strategies to Access Fluorinated Azoles
Abd El-Gaber, M. K.; Djugovski, M.; Huang, T.-Y.; Adhikari, S.; Roy, S. — European Journal of Organic Chemistry (2025)
2. 1,2,4-Triazole-based first-in-class non-nucleoside inhibitors of bacterial enzyme MraY
Berida, T.; Huang, T.-Y.; Weck, S.; Lutz, M.; McKee, S.; Kagerah, N.; Manning, D.; Jahan, M.; Mishra, S.; Hermann, J.; Muller, R.; Doerksen, R.; Stallings, C.; Christian Ducho, C.; Roy, S. — ACS Bio & Med Chem Au (2025)
Non-peer-reviewed preprint: bioRxiv 2025
3. HuR inhibition reduces post-ischemic cardiac remodeling by dampening myocyte-dependent inflammatory gene expression and the innate immune response
Slone, S.; Anthony, S. R.; Green, L. C.; Parkins, S.; Acharya, P.; Kasprovic, D. A.; Reynolds, K.; Jaggers, R. M.; Nieman, M. L.; Alam, P.; Wu, X.; Roy, S.; Aubé, J.; Xu, L.; Li, Z.; Lorenz, J. N.; Owens, A. P.; Kanisicak, O.; Tranter, M. — The FASEB Journal (2025)
Non-peer-reviewed preprint: bioRxiv 2023
4. Plant Antibacterials: The Challenges and Opportunities
Berida, T.; Adekunle, Y. A.; Dada-Adegbola, H.; Kdimy, A.; Roy, S.; Sarkar, S. D. — Heliyon (2024)
5. Morpholine-mediated defluorinative cycloaddition of gem-difluoroalkenes and organic azides
Huang, T.-Y.; Djugovski, M.; Manning, D. L.; Adhikari, S.; Roy, S. — Beilstein Journal of Organic Chemistry (2023)
Non-peer-reviewed preprint: ChemRxiv, 2023
6. Discovery, Synthesis, and Optimization of 1,2,4-Triazolyl Pyridines Targeting Mycobacterium tuberculosis
Berida, T.; McKee, S. R.; Chatterjee, S.; Li, W.; Pandey, P.; Tripathi, S. D.; Doerksen, R. D.; Jackson, M.; Ducho, C.; Stallings, C. L.; Roy, S. — ACS Infectious Diseases (2023)
Non-peer-reviewed preprint: bioRxiv, 2023
7. The challenges and opportunities of developing small molecule inhibitors of MraY
Manning, D. L.; Huang, T.-Y.; Roy, S. — Annual Reports in Medicinal Chemistry (2023)
Invited Review
8. Small molecules targeting the RNA-binding protein HuR inhibit tumor growth in xenografts
Wu, X.; Ramesh, R.; Wang, J.; Zheng, Y.-G.; Armaly, A.; Wei, L.; Xing, M.; Roy, S.; Lan, L.; Gao, P.; Miao, Y.; Xu, L.; Aubé, J. — Journal of Medicinal Chemistry (2023)
9. HuR-dependent expression of Wisp1 is necessary for TGF-induced cardiac myofibroblast activity
Green, L. C; Slone, S.; Anthony, S. R.; Guarnieri, A. Parkins, S.; Shearer, S. M.; Neiman, M. L.; Roy, S.; Aubé, J.; Wu, X.; Xu, L., Tranter, M. — Journal of Molecular and Cellular Cardiology (2023)
10. Identification of Potential Non-nucleoside MraY Inhibitors for Tuberculosis Chemotherapy from Structure-Based Virtual Screening
Pandey, P.; Chatterjee, S.; Berida, T.; Doerksen, R. J.; Roy, S. — Journal of Biomolecular Structure & Dynamics (2022)
11. Optimization Rules for SARS-CoV-2 Mpro Antivirals: Ensemble Docking and Exploration of the Coronavirus Protease Active Site
Stoddard, S. V.; Stoddard, S. D; Oelkers, B. K.; Fitts, K.; Whalum, K.; Hemphill, A. D.; Manikonda, J.; Martinez, L. M.; Riley, E. G.; Roof, C. M.; Sarwar, N.; Thomas, D. M.; Ulmer, E.; Wallace, F. E.; Pandey, P.; Roy, S. — Viruses (2020)
12. Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis
Wu, X.; Gardashova, G.; Lan, L.; Han, S.; Zhong, C.; Marquez, R.; Wei, L.; Wood, S.; Roy, S.; Gowthaman, R.; Karanicolas, J.; Gao, P.; Dixon, D.; Welch, D.; Li, L.; Ji, M.; Aubé, J.; Xu, L. — Communications Biology (2020)
13. Regioselective synthesis of 4-fluoro-1,5-disubstituted-1,2,3-triazoles from synthetic surrogates of α-fluoroalkynes
Jana, S.; Adhikari, S.; Cox, M. R.; Roy, S. — Chemical Communications (2020)
14. HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A
Andrade, D.; Mehta, M.; Griffith, J.; Oh, S.; Corbin, J.; Babu, A.; De, S.; Chen, A.; Zhao, Y. D.; Husain, S.; Roy, S.; Xu, L.; Aube, J.; Janknecht, R.; Gorospe, M.; Herman, T.; Ramesh, R.; Munshi, A. — Cancers (2019)
15. The HuR CMLD-2 Inhibitor Exhibits Antitumor Effects via MAD2 Downregulation in Thyroid Cancer Cells
Allegri, L.; Baldan, F.; Roy, S.; Aubé, J.; Russo, D.; Filetti, S.; Damante, G. — Scientific Reports (2019)
16. Human Antigen R as a Therapeutic Target in Pathological Cardiac Hypertrophy
Green, L.G.; Anthony, S. R.; Slone, S.; Lanzillotta, L.; Nieman, M. L.; Wu, X.; Robbins, N.; Jones, S. M.; Roy, S.; Owens, A. P.; Aubé, J.; Xu, L.; Lorenz, J. N.; Blaxall, B. C.; Rubinstein, J.; Benoit, J. B.; Tranter, M. — JCI Insight (2019)
17. Identification of Antimalarial Inhibitors Using Late-Stage Gametocytes in a Phenotypic Live/Dead Assay
Spicer, T. P.; Gardiner, D. L.; Schoenen, F. J.; Roy, S.; Griffin, P. R.; Chase, P.; Scampavia, L.; Hodder, P.; Trenholme, K. R. — SLAS DISCOVERY: Advancing Life Sciences R&D (2019)
18. Hexafluoroisopropanol and Acetyl Chloride Promoted Catalytic Hydroarylation with Phenols
Roy, S.; Motiwala, H. M.; Koshlap, K. M.; Aubé, J. — European Journal of Organic Chemistry (2018)
19. HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells
Muralidharan, R.; Mehta, M.; Ahmed, R.; Roy, S.; Xu, L.; Aubé, J.; Chen, A.; Zhao, Y.; Herman, T.; Ramesh, R.*; Munshi, A. — Scientific Reports (2017)
20. N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore
Roy, S.*; Sileikyte, J.; Neuenswander, B.; Hedrick, M. P.; Chung, T. D. Y.; Aubé, J.; Schoenen, F. J.*; Forte M. A.*; Bernardi, P. — ChemMedChem (2016)
*co-corresponding author
21. Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore
Roy, S.; Sileikyte, J.; Schiavone, M.; Neuenswander, B.; Argenton, F.; Aubé, J.; Hedrick, M. P.; Chung, T. D. Y.; Forte M. A.; Bernardi, P.; Schoenen, F. J. — ChemMedChem (2015)
Designated as Very Important Paper (VIP)
22. A Practical and Scalable Synthesis of (S)- and (R)-1-(Dimethoxyphosphoryl)allyl Methyl Carbonates
Roy, S.; Sutivisedsak, N.; Hamper, B. C.; Lyss, A. M.; Spilling, C. D. — Synthesis (2015)
23. Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2 Amidinophenylbenzamides as Potent Inhibitors of Venezuelan Equine Encephalitis Virus
Schroeder, C. E.; Yao, Y.; Sotsky, J.; Smith, R. A.; Roy, S.; Chu, Y-K, Guo, H.; Tower, N. A.; Noah, J. W.; McKellip, S.; Sosa, M.; Ramussen, L.; Smith, L. H.; White. E. L.; Aubé, J.; Jonsson, C. B.; Chung, D.; Golden, J. E. — Journal of Medicinal Chemistry (2014)
24. Small Molecules Targeting the Mitochondrial Permeability Transition
Sileikyte, J.; Roy, S.; Porubsky, P.; Neuenswander, B.; Wang, J.; Hedrick, M.; Pinkerton, A. B.; Salaniwal, S.; Kung, P.; Mangravita-Novo, A.; Smith, L. H.; Bourdette, D. N.; Jackson, M. R.; Aubé, J; Chung, T. D. Y.; Schoenen, F. J.; Forte M. A.; Bernardi, P. — Probe Reports from the NIH Molecular Libraries Program (2014)
25. ML336: Development of Quinazolinone-Based Inhibitors Against Venezuelan Equine Encephalitis Virus (VEEV)
Chung, D.; Schroeder, C. E.; Sotsky, J.; Yao, T.; Roy, S.; Smith, R. A.; Tower, N. A.; Noah, J. A.; McKellip, S.; Sosa, M.; Rasmussen, L.; White, E. L.; Aubé, J.; Golden, J. E. — Probe Reports from the NIH Molecular Libraries Program (2013)
26. An Expeditious Total Synthesis of Both Diastereomeric Lipid Dihydroxytetrahydrofurans from Notheia Anomala
Roy, S.; Spilling, C. D.* — Organic Letters (2012)
27. Synthesis of the C(18)-C(34) Fragment of Amphidinolide C and the C(18)-C(29) Fragment of Amphidinolide F
Roy, S.; Spilling, C. D. — Organic Letters (2010)
28. A Task Specific Basic Ionic Liquid, [BmIm]OH-promoted Efficient green and One-pot Synthesis of Tetrahydrobenzo[b]pyran Derivatives
Ranu, B. C.; Banerjee, S.; Roy, S. — Indian Journal of Chemistry (2008)